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Nicotine Metabolite Ratio (3-Hydroxycotinine/Cotinine) in Plasma and Urine by Different Analytical Methods and Laboratories: Implications for Clinical Implementation.

机译：不同分析方法和实验室在血浆和尿液中的尼古丁代谢物比率（3-羟可宁/可替宁）：对临床实施的意义。

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摘要

The highly genetically variable enzyme CYP2A6 metabolizes nicotine to cotinine (COT) and COT to trans-3'-hydroxycotinine (3HC). The nicotine metabolite ratio (NMR, 3HC/COT) is commonly used as a biomarker of CYP2A6 enzymatic activity, rate of nicotine metabolism, and total nicotine clearance; NMR is associated with numerous smoking phenotypes, including smoking cessation. Our objective was to investigate the impact of different measurement methods, at different sites, on plasma and urinary NMR measures from ad libitum smokers.

机译：高度遗传可变的酶CYP2A6将尼古丁代谢为可替宁（COT），将COT代谢为反式3'-羟基烟碱（3HC）。尼古丁代谢物比率（NMR，3HC / COT）通常用作CYP2A6酶活性，尼古丁代谢率和总尼古丁清除率的生物标记。 NMR与许多吸烟表型有关，包括戒烟。我们的目标是调查在任意场所使用不同测量方法对随意吸烟者血浆和尿NMR测量的影响。

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Tanner, Julie-Anne; Novalen, Maria; Jatlow, Peter; Huestis, Marilyn A; Murphy, Sharon E; Kaprio, Jaakko; Kankaanpää, Aino; Galanti, Laurence; Stefan, Cristiana; George, Tony P; Benowitz, Neal L; Lerman, Caryn; Tyndale, Rachel F;
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1. Nicotine Metabolite Ratio (3-Hydroxycotinine/Cotinine) in Plasma and Urine by Different Analytical Methods and Laboratories: Implications for Clinical Implementation [J] . Tanner Julie-Anne, Novalen Maria, Jatlow Peter, Cancer epidemiology, biomarkers and prevention: A publication of the American Association for Cancer Research . 2015,第8期

机译：不同分析方法和实验室在血浆和尿液中尼古丁代谢物的比率（3-羟可宁/可替宁）：对临床实施的意义
2. Urine nicotine metabolite concentrations in relation to plasma cotinine during low-level nicotine exposure [J] . Neal L. Benowitz Katherine M. Dains Delia Dempsey Brenda Herrera Lisa Yu and Peyton Jacob III Nicotine & Tobacco Research . 2009,第8期

机译：低水平尼古丁暴露期间尿液中尼古丁代谢物浓度与血浆可替宁的关系
3. Urine nicotine metabolite concentrations in relation to plasma cotinine during low-level nicotine exposure. [J] . Nicotine & Tobacco Research . 2009,第8期

机译：低水平尼古丁暴露期间尿中尼古丁代谢物的浓度与血浆可替宁的关系。
4. A Turbulent-Flow LC-MS Method to Measure Nicotine and Cotinine in Plasma and Urine Samples. [C] . Joseph M. Di Bussolo, Hidehiko Azumaya, Felix Boakye-Agyeman ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：一种湍流流动LC-MS方法，用于测量血浆和尿液样品中的尼古丁和胞苷。
5. Part One. Development of analytical methods for the determination of selected "organic pesticides". Part Two. DDT and its metabolites in soil and air at an agricultural site near South Haven, Michigan: Determination and implications. [D] . Vandervoort, Christine. 2000

机译：第一部分。开发用于确定所选“有机农药”的分析方法。第二部分。在密歇根州南黑文附近的一个农业地点，土壤和空气中的滴滴涕及其代谢物：测定和意义。
6. Nicotine Metabolite Ratio (3-hydroxycotinine/cotinine) in Plasma and Urine by Different Analytical Methods and Laboratories: Implications for Clinical Implementation [O] . Julie-Anne Tanner, Maria Novalen, Peter Jatlow, -1

机译：不同分析方法和实验室在血浆和尿液中的尼古丁代谢物比率（3-羟基烟碱/烟碱）：对临床实施的意义
7. Nicotine Metabolite Ratio (3-Hydroxycotinine/Cotinine) in Plasma and Urine by Different Analytical Methods and Laboratories: Implications for Clinical Implementation [O] . Tanner, Julie-Anne, Novalen, Maria, Jatlow, Peter, 2015

机译：不同分析方法和实验室对血浆和尿液中尼古丁代谢物比率（3-羟基甘氨酸/可替宁）的影响：临床实施的意义
8. Cotinine Analytical Workshop Report: Consideration of Analytical Methods for Determining Cotinine in Human Body Fluids as a Measure of Passive Exposure to Tobacco Smoke [R] . Watts, R. R., Langone, J. J., Knight, G. J., 1990

机译：可替宁分析研讨会报告：考虑用于测定人体体液中可替宁作为被动暴露于烟草烟雾的量度的分析方法

Nicotine Metabolite Ratio (3-Hydroxycotinine/Cotinine) in Plasma and Urine by Different Analytical Methods and Laboratories: Implications for Clinical Implementation.

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